| Wed 10/21 8:00 PM ET | New Mexico State Aggies | -2.5 | @ Sam Houston Bearkats |
| Thu 10/22 7:00 PM ET | James Madison Dukes | -10.5 | @ Appalachian State Mountaineers |
| Thu 10/22 7:00 PM ET | Liberty Flames | -10.5 | @ Kennesaw State Owls |
| Thu 10/22 7:30 PM ET | @ Memphis Tigers | -9.5 | East Carolina Pirates |
| Fri 10/23 7:00 PM ET | @ Virginia Cavaliers | -1.5 | Duke Blue Devils |
| Fri 10/23 7:00 PM ET | @ UConn Huskies | -14.5 | UMass Minutemen |
| Fri 10/23 8:30 PM ET | @ Tulsa Golden Hurricane | -1.5 | Army Black Knights |
| Fri 10/23 9:00 PM ET | Air Force Falcons | -4.5 | @ Wyoming Cowboys |
| Fri 10/23 10:30 PM ET | North Carolina State Wolfpack | -6.5 | @ Stanford Cardinal |
| Sat 10/24 12:00 PM ET | @ TCU Horned Frogs | -8.5 | West Virginia Mountaineers |
| Sat 10/24 12:00 PM ET | Texas Tech Red Raiders | -10.5 | @ Cincinnati Bearcats |
| Sat 10/24 12:00 PM ET | LSU Tigers | -7.5 | @ Auburn Tigers |
| Sat 10/24 12:00 PM ET | @ SMU Mustangs | -19.5 | California Golden Bears |
| Sat 10/24 12:00 PM ET | @ Florida Atlantic Owls | -7.5 | Rice Owls |
| Sat 10/24 12:00 PM ET | @ Miami (FL) Hurricanes | -20.5 | Pittsburgh Panthers |
| Sat 10/24 12:00 PM ET | Indiana Hoosiers | -7.0 | @ Michigan Wolverines |
| Sat 10/24 12:00 PM ET | @ Toledo Rockets | -3.0 | Western Michigan Broncos |
| Sat 10/24 1:00 PM ET | @ Kent State Golden Flashes | -3.0 | Akron Zips |
| Sat 10/24 1:00 PM ET | Baylor Bears | -3.0 | @ Kansas Jayhawks |
| Sat 10/24 1:00 PM ET | Miami (OH) RedHawks | -2.5 | @ Central Michigan Chippewas |
| Sat 10/24 3:00 PM ET | Oregon Ducks | -9.0 | @ Illinois Fighting Illini |
| Sat 10/24 3:30 PM ET | @ Alabama Crimson Tide | -14.0 | Texas A&M Aggies |
| Sat 10/24 3:30 PM ET | @ Ball State Cardinals | -14.0 | Sacramento State Hornets |
| Sat 10/24 3:30 PM ET | Iowa Hawkeyes | -7.0 | @ Minnesota Golden Gophers |
| Sat 10/24 3:30 PM ET | Hawai'i Rainbow Warriors | -4.5 | @ Northern Illinois Huskies |
| Sat 10/24 3:30 PM ET | BYU Cougars | -6.5 | @ UCF Knights |
| Sat 10/24 3:30 PM ET | Oklahoma Sooners | -4.0 | @ Mississippi State Bulldogs |
| Sat 10/24 3:30 PM ET | @ UCLA Bruins | -14.0 | Michigan State Spartans |
| Sat 10/24 3:30 PM ET | North Texas Mean Green | -2.5 | @ Navy Midshipmen |
| Sat 10/24 3:30 PM ET | @ Georgia Tech Yellow Jackets | -4.0 | Boston College Eagles |
| Sat 10/24 3:30 PM ET | @ South Carolina Gamecocks | -2.5 | Tennessee Volunteers |
| Sat 10/24 3:30 PM ET | @ Buffalo Bulls | -3.5 | Bowling Green Falcons |
| Sat 10/24 3:45 PM ET | Kansas State Wildcats | -3.5 | @ Arizona State Sun Devils |
| Sat 10/24 4:00 PM ET | @ Ohio Bobcats | -12.0 | Eastern Michigan Eagles |
| Sat 10/24 4:00 PM ET | @ Troy Trojans | -15.0 | Louisiana-Monroe Warhawks |
| Sat 10/24 5:00 PM ET | Louisiana Ragin' Cajuns | -10.0 | @ Southern Miss Golden Eagles |
| Sat 10/24 5:00 PM ET | @ Louisiana Tech Bulldogs | -12.0 | Old Dominion Monarchs |
| Sat 10/24 5:00 PM ET | @ Nevada Wolf Pack | -5.0 | San Jose State Spartans |
| Sat 10/24 6:00 PM ET | Boise State Broncos | -12.5 | @ Washington State Cougars |
| Sat 10/24 6:30 PM ET | San Diego State Aztecs | -1.0 | @ Colorado State Rams |
| Sat 10/24 7:00 PM ET | Georgia State Panthers | -2.0 | @ Arkansas State Red Wolves |
| Sat 10/24 7:00 PM ET | @ Oklahoma State Cowboys | -12.5 | Colorado Buffaloes |
| Sat 10/24 7:00 PM ET | @ Clemson Tigers | -3.0 | Virginia Tech Hokies |
| Sat 10/24 7:30 PM ET | USC Trojans | -3.0 | @ Wisconsin Badgers |
| Sat 10/24 7:30 PM ET | @ Kentucky Wildcats | -11.0 | Vanderbilt Commodores |
| Sat 10/24 7:30 PM ET | @ North Carolina Tar Heels | -8.0 | Syracuse Orange |
| Sat 10/24 7:30 PM ET | @ Arizona Wildcats | -10.0 | Iowa State Cyclones |
| Sat 10/24 7:30 PM ET | @ Texas State Bobcats | -12.5 | Utah State Aggies |
| Sat 10/24 7:30 PM ET | @ Texas Longhorns | -3.0 | Mississippi Rebels |
| Sat 10/24 8:00 PM ET | UTSA Roadrunners | -2.5 | @ Tulane Green Wave |
| Sat 10/24 10:00 PM ET | @ New Mexico Lobos | -4.5 | North Dakota State Bison |
| Sat 10/24 10:15 PM ET | @ Utah Utes | -6.5 | Houston Cougars |